Can be on anything to do with microbiology (you can choose the topic) Article

Can be on anything to do with microbiology (you can choose the topic) - Article Example Basically, 3 are 3 laboratory tests useful for the diagnosis of dengue infection and they are viral isolation in culture, detection of viral RNA, and specific IgM/IgG antibodies in paired sera. The gold standard for diagnosis is a combination of these 3 tests. However, it is not practice to do all the 3 tests in a patient at a particular setting. Viral isolation is expensive, needs technology and results are obtained after 6 - 10 days, which ia very late for initiation of management and hence this test cannot be used regularly. PCR technique results are ofcourse fast, but are expensive and not available in all clinical settings. Immunochromatographic and ELISA tests for the detection of IgM/IgG antibodies which give results within minutes or few hours, but these antibodies can be detected only after 4-5 days of onset of the disease. Also, paired sera samples showing seroconversion or a fourfold titer increase are essential to confirm diagnosis.